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Thursday, May 31, 2012
Envoy: 'Very clear' signs of Iran sanitizing military site
DigitalGlobe - ISIS
This satellite image from Friday shows earth displacement activity at the suspected high explosive testing site in Parchin, Iran. The U.N.'s nuclear watchdog has repeatedly asked Iran for access to the site as part of a long-stalled probe into suspicions that Tehran may be seeking the ability to assemble nuclear bombs.
By msnbc.com and news services
VIENNA -- U.N. nuclear inspectors displayed new satellite imagery on Wednesday indicating that some small buildings had been dismantled and other possible clean-up work undertaken at an Iranian military site they want to visit.
One image from May 25 showed signs that "ground-scraping activities" had taken place at the Parchin facility, as well as the presence of a bulldozer, according to diplomats who attended a closed-door briefing by U.N. nuclear agency officials.
This will likely further strengthen Western suspicions that Iran is "sanitizing" the site of any incriminating evidence before allowing the International Atomic Energy Agency (IAEA) into the complex. "It is very clear," one Western envoy said.
Diplomatic talks aimed at curbing Iran's nuclear ambitions have ended with no major breakthrough. NBC's Ali Arouzi reports.
Iran's IAEA envoy, Ali Asghar Soltanieh, dismissed such accusations by Western officials, telling reporters after the briefing that "this kind of noise and allegations are baseless".
Israel's Barak to NBC: Nuclear Iran unacceptable
The images?released by the Institute for Science and International Security's (ISIS) could hurt a tentative deal between?the U.N.'s atomic watchdog aimed at giving inspectors wide access to scientists, documents and facilities?allegedly related to nuclear-weapons work, The Wall Street Journal reported.?
Wednesday's disclosure followed inconclusive talks between Iran and six world powers in Baghdad last week to address concerns about the nature of its nuclear activities, which Iran says are aimed at generating electricity.
The images were?posted on ISIS's website hours after diplomats said the International Atomic Energy Agency?showed what appeared to be similar imagery at a closed-door briefing in Vienna.?
Israel's defense minister Ehud Barak said his country will do "whatever it takes" to prevent Iran from becoming a military power with a nuclear weapon. NBC's Richard Engel reports.
The agency has been pressing Iran to allow inspectors to visit the Parchin military facility, which the IAEA thinks could have been involved in testing of high explosives, the Wall Street Journal reported.
Western envoys who attended Wednesday's briefing earlier told Reuters that two small side buildings at Parchin had been removed, and ISIS said its pictures from May 25 showed that they "have been completely razed." ?
ISIS, which tracks Iran's nuclear program closely, said there were visible tracks in the images "made by heavy machinery used in the demolition process," adding that the two buildings had been intact in early April.?
The U.N. International Atomic Energy Agency (IAEA) has repeatedly asked Iran for access to Parchin as part of a long-stalled probe into suspicions that Tehran may be seeking the ability to assemble nuclear bombs, should it decide to do so.?
Sanctions have taken a toll on the Iranian economy. The government is reluctant to admit it. Inflation is high. The number of young unemployed is a growing concern. NBC's Ali Arouzi reports.?
The Islamic state has so far refused to let inspectors visit the facility -- which it describes as a conventional military complex -- saying there must first be a broader framework agreement on how to address the IAEA's questions.?
Report: Iran using passenger jets to smuggle weapons to Syria, Lebanon
United Nations weapons inspectors have reportedly discovered traces of radio activity inside a nuclear bunker in Iran. Former U.S. ambassador Mark Ginsberg joins MSNBC to talk about the situation.
The Parchin complex is at the center of Western allegations that Iran has been conducting research and experiments that could serve a nuclear weapons development programme. The Islamic Republic has repeatedly denied any such ambition.?
Iran state TV: We'll build second nuclear plant
Last week, the IAEA said in a report issued to member states that satellite images showed "extensive activities" at the facility southeast of Tehran.?
Western diplomats said this was an allusion to suspected cleaning at Parchin. They have earlier cited other images showing recent activity at the site, including a stream of water, as suggesting Iran is trying to remove evidence.?
Iran says it will take part in another round of nuclear negotiations in June after meetings in Baghdad with six world powers ended on Thursday. NBC's Ali Arouzi reports.
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Iran, big powers agree to another round of nuclear talks
An IAEA report last November said Iran had built a large containment vessel in 2000 at Parchin in which to conduct tests that the U.N. agency said were "strong indicators of possible (nuclear) weapon development."?
It said a building was constructed around a large cylindrical object, a vessel designed to contain the detonation of up to 70 kg of high explosives. Diplomatic sources say the suspected tests likely took place about a decade ago.?
Last week, a senior Iranian official was quoted as saying the IAEA had not yet given good enough reasons to visit Parchin.?
Reuters contributed to this report.
More world news from msnbc.com and NBC News:
Follow us on Twitter: @msnbc_world
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Trump birther remarks overshadow Romney appearance
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Saturday, May 26, 2012
Cancer may require simpler genetic mutations than previously thought
Friday, May 25, 2012
Chromosomal deletions in DNA often involve just one of two gene copies inherited from either parent. But scientists haven't known how a deletion in one gene from one parent, called a "hemizygous" deletion, can contribute to cancer.
A research team led by Stephen Elledge, a professor in the Department of Genetics at Harvard Medical School, and his post-doctoral fellow Nicole Solimini, has now provided an answer. The most common hemizygous deletions in cancer, their research shows, involve a variety of tumor suppressing genes called STOP genes (suppressors of tumorigenesis and proliferation) that scatter randomly throughout the genome, but that sometimes cluster in the same place on a chromosome. And these clusters, said Elledge, who is also a professor of medicine at Brigham and Women's Hospital, tend to be deleted as a group. "Eliminating the cluster gives a bigger bang for the deletion buck," he said.
This finding is especially interesting in light of the two-hit model of cancer formation, which holds that both copies of a recessive gene need to be inactivated to trigger a biological effect. Thus the loss of a single tumor suppressor copy should have little or no influence on tumor cell proliferation because the remaining copy located on the other chromosome is there to pick up the slack.
Elledge's research points to a different hypothesis, namely that STOP genes in a hemizygous deletion aren't recessive but are instead haploinsufficient, meaning that they depend on two copies to function normally. "If a tumor suppressor is haploinsufficient, then a single gene copy lacks the potency needed to fully restrain tumorigenesis," Elledge explained, who is also a Howard Hughes Medical Institute Investigator. "So by removing clusters of haploinsufficient genes all at once, the cancer cell immediately propels its growth forward without having to wait for the other copies to also be lost."
Angelika Amon, a professor of biology at the Massachusetts of Technology, said she's surprised by the findings. "We've known from a lot of human syndromes that haploinsufficiency is widespread in the development of complex multicellular organisms," she said. "But these data show it's also critical for individual cells and cell proliferation."
The results also offer a different take on the two-hit model in carcinogenesis, Amon said. Being remarkably unstable, cancer cells can delete gene copies at every turn of the corner. If the loss of a single tumor suppressor copy provides no survival advantage for the tumor, then the tumor has no incentive to retain the cell with that deletion. But if the loss of that copy boosts proliferation, then the probability of a second hit later is greatly increased. "So haploinsufficiency is a way for the cancer cell to dramatically accelerate the acquisition of growth beneficial mutations," Amon said.
In other words, all it takes is a 50 percent reduction in gene activity for a cancer cell to grow. "That tells us it's a lot easier to get cancer than we might have hoped," Amon said.
According to Elledge, the number of hemizygotic deletions averages roughly six per tumor, with some tumors?breast and pancreatic, for instance?averaging up to ten. Each deletion involves 25 to 40 genes, many of them STOP genes, but also a few GO genes (growth enhancers and oncogenes) that enhance proliferation. That the STOP genes substantially outnumber their GO counterparts is important, Elledge explained, because it means cancer cells can tilt scales toward proliferation without also compromising it at the same time.
"The data reveal a lot of haploinsufficient players that have small effects individually, but large effects in combination," Elledge said. "Unfortunately, it's not easy to see how to take advantage of that chemotherapeutically."
What's important about the results, he emphasized, is that they open up new views on how tumors evolve. Moreso, they underscore the importance of proliferation as a fundamental feature of tumor growth, he added.
The challenge now, Elledge said, will be to find out which of the genes in a recurring deletion are haploinsufficient. "At the moment, we estimate roughly 25 percent," he said. "So these findings could also have important ramifications for other human diseases in addition to cancer."
###
Science, May 24, 2012
"Recurrent Hemizygous Deletions in Cancers May Optimize Proliferative Potential," by Solimini et al.
Harvard Medical School: http://hms.harvard.edu
Thanks to Harvard Medical School for this article.
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
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Thursday, May 24, 2012
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Holy Motors! Minogue, Mendes in madcap Cannes movie
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Tuesday, May 22, 2012
Obtain Relaxed And Enjoy Online Video games - NN Open
Fun is needed by everyone on this particular earth. It will help one to obtain prepared for that work as well as provides rest. People follow various ways of get fun throughout their tight operating schedules. These types of could consist of listening associated with music, viewing videos, doing offers etc. Gaming is actually one activity that?s popular amongst children in addition to adults similarly. With the aid of this exercise, you obtain the strength for future years work. This pokies produces an exhilaration in body and mind and makes the life span enjoyable.
There are various kinds of gaming actions. These could be as sports, interior games and so on. New forms that have developed using the advancement within technology tend to be computer and game titles. Computer games would be the frolics that you simply play on your pc screens whilst sitting in your home. These could be further classified in various categories. Within the terms associated with themes, these could be categorised because racing, battling, adventure, as well as castle and so on. and might be played on the internet and offline too. Online types are those that you perform on numerous websites on Internet, whereas traditional ones tend to be played without the aid of Internet.
Several video gaming consoles are providing a number of frolics towards the users. A number of latest games exist in the actual markets that offer fun towards the people. They are developed upon latest Expensive technology. Mentionened above previously earlier, these enjoyable activities can be found in many themes for example racing, battling etc. Racing video games are individuals in that you?ve to run your automobile like a car or perhaps a bike on the road. In case your vehicle reaches in the beginning position, then you definitely are declared like a winner and also you are enables to perform next higher-level. Fighting video games have attracted the folks since lengthy. In these types of your player needs to fight using the other gamers. They can be found in two variations ? 2 players as well as multi gamers. If you?re playing within multi-players setting then it might become harder that you should win this. In many others you get involved with some experience like busting a fortress or invading the actual enemy place.
More and much more latest games are now being offered by lots of websites. These types of sites help the customers to perform the video games with a lot excitement. Many of these activities need the assistance of Expensive technology. It allows the machine to show the graphical information on these actions. Some from the sites supply the facility associated with downloading about the hard drive also. This facility enables you to play traditional also, without connecting towards the Internet. This facility is extremely good when you have slow cable connections. By downloading it, you may enjoy all of them even if you don?t have higher speed Web connection available.
Many much more latest games are now being supported through different video gaming consoles. Individuals are enjoying them a great deal these times. Hopefully, we can get much much more exciting video games in long term also.
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